Department of Hematology

Institute of Medical Sciences
College of Medical Sciences
University of Rzeszow

Prof. dr hab. n. med. Mirosław Markiewicz - Medical university of Rzeszow Poland

Head of Department of Hematology

Prof. Miroslaw Markiewicz, M.D., Ph.
[email protected]

Tel: 17/ 86 66 645

Contact to the Department of Hematology

Department of Hematology
Fryderyk Chopin University Clinical Hospital

 

2 Szopena St., 35-055 Rzeszów
Tel: 17/ 86 66 609 Fax: 17/ 86 66 608
Email: hematologia@szpital.rzeszow.pl

Department of Hematology Medical University of Rzeszow Poland

Department of Hematology Medical University of Rzeszow Poland

 

Major scientific achievements

  • Own and inter-center scientific research in the field of optimization of diagnosis and treatment of hematopoietic diseases carried out, among others:

- Own projects

- Polish Adult Leukemia Treatment Group (PALG)

- Polish Lymphoma Research Group

  • Publications in Polish and international scientific journals
  • Leader of the University of Rzeszow - 2019.
  • The work of the Hematological Student Scientific Circle
  • Awarded a grant from the Minister of Education and Science under the Student Scientific Circles Create Innovations program (2022) for the implementation of the project Significance of clinical and genetic risk factors in chronic lymphocytic leukemia

Key teaching achievements

  • Didactic classes with students of the Medical Faculty and English Division of the College of Medical Sciences of the University of Rzeszow
  • Specialization training of physicians in the field of hematology
  • Hematology training of physicians from other centers within the framework of directed internships
  • Specialization training of laboratory diagnosticians in cytomorphological, immunophenotypic, cytogenetic and molecular biology diagnostics
  • Distinction by graduates of the Faculty of Medicine - 2022 y.

 

Full-time employees

Prof. Miroslaw Markiewicz, MD, PhD

Agnieszka Kopacz, MD

Dr. Beata Blajer-Olszewska

Dr. Katarzyna Warzybok

Dr. Jarosław Grzyb

Dr. Aleksandra Rejus-Gajdek

 

LIST OF PUBLICATIONS

  1. Markiewicz M. Characteristics of oxycodone use in the treatment of cancer and non-cancer pain in specialized medical practice in Poland. Results of a multicenter observational study. Published by Accord Healthcare Polska Sp. z o.o., 7 Taśmowa St., 02-677 Warsaw, 2019: 1-7.

 

  1. Canaani J, Beohou E, Labopin M, Ghavamzadeh A, Beelen D, Hamladij Rose-M, Niederwieser D, Volin L, Markiewicz M, Arnold R, Mufti G, Ehninger G, Kroger N, Mohty M, Nagler A. Trends in patient outcome over the past two decades following allogeneic stem cell transplantation for acute myeloid leukemia. An ALWP/EBMT analysis. J Intern Med 2019, 285 (4): 407-418.

 

  1. Miano M, Eikema DJ, Aljurf M, Van't Veer Pieter J., Ozturk Gulyuz, Wolfl Matthias, Smiers Frans, Schulz Ansgar, Socie Gerard, Vettanranta Kim, Diaz de Heredia Cristina, Zecca Marco, Maertens Johan, Rovira Montserrat, Sierra Jorge, Uckan-Cetinkaya Duygu, Skorobogatova Elena, Antmen Ali Bulent, Dalle Jean-Gugues, Markiewicz M, Hamladij Rose Marie, Kitra-Roussou Vassiliki, La Nasa Giorgio, Krivan Gergely, Al-Seiraihy Amal, Giardino Stefano, Risitano Antonio Maria, Peffault de Latour Regis, Dufour Carlo. Stem cell transplantation for congenital dyserythropoietic anemia. An analysis from the European society for blood and marrow transplantation. Haematologica 2019, 104(8): e335-e339; doi:10.3324/haematol.2018.206623.

 

  1. Beelen DW, Trenschel R, Stelljes M, Groth C, Masszi T, Reményi P, Wagner-Drouet EM, Hauptrock B, Dreger P, Luft T, Bethge W, Voge Wl, Ciceri F, Peccatori J, Stölzel F, Schetelig J, Junghanß C, Grosse-Thie C, Michallet M, Labussiere-Wallet H, Schaefer-Eckart K, Dressler S, Grigoleit GU, Mielke S, Scheid C, Udo Holtick U, Patriarca F, Medeot M, Rambaldi A, Micò MC, Niederwieser D, Franke GN, Hilgendorf I, Winkelmann NR, Russo D, Socié G, de Latour RP, Holler E, Wolff D, Glass B, Casper J, Wulf G, Menzel H, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, Grass S, Iori AP, Finke J, Benedetti F, Pichlmeier U, Hemmelmann C, Tribanek M, Klein A, Mylius HA, Baumgart J, Dzierzak-Mietla M, Markiewicz M. Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial. Lancet Haematol2020; 7(1): e28-e39. doi: 10.1016/S2352-3026(19)30157-7.

 

  1. Markiewicz M, Drozd-Sokolowska J, Biecek P, Dzierzak-Mietla M, Boguradzki P, Staniak M., Piatkowska-Jakubas B, Piekarska A., Tormanowska M, Halaburda K, Ussowicz M, Waszczuk-Gajda A, Basak G, Bołkun Ł, Rybka J, Sadus-Wojciechowska M, Giebel S, Szmigielska-Kaplon A., Mendek-Czajkowska E, Warzybok K, Burdacki A, Dwilewicz-Trojaczek J. Allogeneic Hematopoietic Stem Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Multicenter Analysis by the Polish Adult Leukemia Group. Biol Blood Marrow Transplant 2020; 20: 30347–55.

 

  1. Markiewicz M, Dzierżak-Mietła M, Gaj M, Warzybok K, Burdacki A, Mizia S. Similar effectiveness of Fomukal and Caphosol in oral mucositis treatment after allogeneic hematopoietic stem cell transplantation.Postepy Hig Med Dosw 2020, 74: 541-547.

 

  1. Macauda, A, Piredda, C, Clay‐Gilmour, AI, Sainz J, Buda G, Markiewicz M, Barington T, Ziv E, Hildebrandt MAT, Belachew AA, Varkonyi J, Prejzner W, Druzd‐Sitek A, Spinelli J, Andersen NF, Hofmann JN, Dudziński M, Martinez‐Lopez J, Iskierka‐Jazdzewska E, Milne RL, Mazur G, Giles GG, Ebbesen LH, Rymko M, Jamroziak K, Subocz E, Reis RM, Garcia‐Sanz R, Suska A, Haastrup EK, Zawirska D, Grzasko N, Vangsted AJ, Dumontet C, Kruszewski M, Dutka M, Nicola J. Camp NJ, Waller RG, Tomczak W, Pelosini M, Raźny M, Marques H, Abildgaard N, Wątek M, Jurczyszyn A, Brown EE, Berndt S, Butrym A, Vachon CM, Norman AD, Slager SL, Gemignani F, Canzian F, Campa D. Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients. Int J Cancer 2021; 149(2): 327-336.

 

  1. Orlewska K, Bogusz K, Podlecka-Piętowska A, Nojszewska M, Markiewicz M, Liwoch R, Orlewski P, Śliwczyński A, Zakrzewska-Pniewska B, Snarski E.  Impact of Immunoablation and Autologous Hematopoietic Stem Cell Transplantation (AHSCT) on Treatment Cost of Multiple Sclerosis: Real-World Nationwide Study. Value Health Reg Issues 2021; 25(C): 104–107.

 

  1. Markiewicz M. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria in the era of complement inhibition. Acta Haematologica Polonica 2021; 52(4): 253-256.

 

  1. Opalinska A, Kwiatkowska D, Burdacki A, Markiewicz M, Samotij D, Dudzinski M, Niemiec-Dudek J, Ostanska E, Reich A. Multifocal Pyoderma Gangrenosum with an Underlying Hemophagocytic Lymphohistiocytosis: Case Report and the Review of the Literature. Dermatol Ther (Heidelb)2021; 11(4): 1217-1237.

 

  1. Giaccherini M, Macauda A, Orciuolo E, Rymko M, Gruenpeter K, Dumontet C, Raźny M, Moreno V, Buda G, Beider K, Varkonyi J, Avet-Loiseau H, Martinez-Lopez J, Marques H, Watek M, Sarasquete Maria E, Andersen V, Karlin L, Suska A, Kruszewski M, Abildgaard N, Dudziński M, Butrym A, Nagler A, Vangsted A J, Kadar K, Tomczak W, Jamroziak K, Jacobsen Svend EH, Ebbesen LH, Taszner M, Mazur Grzegorz, Lesueur F, Pelosini M, Garcia-Sanz R, Jurczyszyn A, Demangel D, Reis R M, Iskierka-Jażdżewska E, Markiewicz M, Gemignani F, Subocz E, Zawirska D, Druzd-Sitek A, Stępień A, Alonso MH, Sainz J, Canzian F, Campa D. Genetically determined telomere length and multiple myeloma risk and outcome. Blood Cancer J 2021, 11: 74. https://doi.org/10.1038/s41408-021-00462-y.

 

  1. Rybicka-Ramos M,Markiewicz M, Suszka-Świtek A, Wiaderkiewicz R, Mizia S, Dzierżak-Mietła M, Białas K. Proinflammatory cytokines as potential risk factors of acute graft-versus-host disease and infectious complications after allogeneic hematopoietic stem cell transplantation Am J Blood Res 2021; 11(2): 149-156.

 

  1. Beelen DW, Stelljes M, Reményi P, Wagner-Drouet EM, Dreger P, Bethge W, Ciceri F, Stölzel F, Junghanß C, Labussiere-Wallet H, Schaefer-Eckart K, Grigoleit GU, Scheid C, Patriarca F, Rambaldi A, Niederwieser D, Hilgendorf I, Russo D, Socié G, Holler E, Glass B, Casper J, Wulf G, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, La Rocca U, Finke J, Benedetti F, Pichlmeier U, Klein A, Baumgart J, Markiewicz M. Treosulfan compared with reduced-intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial. Am J Hematol 2022; 97(8): 1023-1034. doi: 10.1002/ajh.26620.

 

  1. Karaś A, Kawałko K, Płaczek A, Warzybok K, Blajer-Olszewska B, Dudziński M, Markiewicz M. Bosutynib w przewlekłej białaczce szpikowej u pacjentów z chorobami współistniejącymi. Świat Medycyny i Farmacji 2022, 5(249): 30-38.

 

  1. Kawalec P, Holko P, Bungey G, Moseley O, Żegleń M, Markiewicz M. Treosulfan-based conditioning vs. low-dose busulfan-based conditioning for allogeneic hematopoietic stem cell transplantation: a cost-utility analysis in Poland. Acta Haematologica Polonica 2022; 53, 3: 75–84.

 

  1. Rybicka-Ramos M, Markiewicz M, Suszka-Świtek A, Wiaderkiewicz R, Mizia S, Dzierżak-Mietła M, Białas K. Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation. World J Biol Chem 2022; 13(4): 72-82.

 

  1. Clavero E, Sanchez-Maldonado JM, Macauda A, Ter Horst R, Sampaio-Marques B, Jurczyszyn A, Clay-Gilmour A, Stein A, Hildebrandt MAT, Weinhold N, Buda G, García-Sanz R, Tomczak W, Vogel U, Jerez A, Zawirska D, Wątek M, Hofmann JN, Landi S, Spinelli JJ, Butrym A, Kumar A, Martínez-López J, Galimberti S, Sarasquete ME, Subocz E, Iskierka-Jażdżewska E, Giles GG, Rybicka-Ramos M, Kruszewski M, Abildgaard N, Verdejo FG, Sánchez Rovira P, da Silva Filho MI, Kadar K, Razny M, Cozen W, Pelosini M, Jurado M, Bhatti P, Dudzinski M, Druzd-Sitek A, Orciuolo E, Li Y, Norman AD, Zaucha JM, Reis RM, Markiewicz M, Rodríguez Sevilla JJ, Andersen V, Jamroziak K, Hemminki K, Berndt SI, Rajkumar V, Mazur G, Kumar SK, Ludovico P, Nagler A, Chanock SJ, Dumontet C, Machiela MJ, Varkonyi J, Camp NJ, Ziv E, Vangsted AJ, Brown EE, Campa D, Vachon CM, Netea MG, Canzian F, Försti A, Sainz J. Polymorphisms within autophagy-related genes as susceptibility biomarkers for multiple myeloma: a meta-analysis of three large cohorts and functional characterization. Int J Mo Sci2023;24,10:8500.

 

Brief description of the scientific activities of the Department

The basis for the scientific activity of the Department of Hematology is its clinical activity-Diagnosis and treatment of proliferative and non-cancerous diseases of the hematopoietic system under contract with the National Health Fund, including, among others, highly specialized therapeutic procedures:

  • Treatment with innovative, costly active substances within the framework of NFZ therapeutic programs dedicated to oncological and non-oncological diseases
  • Chemotherapy and immunotherapy of hematologic and lymphoid malignancies under guaranteed benefits
  • Treatment of other hematological disorders
  • Therapeutic and collection apheresis
  • Autologous and allogeneic hematopoietic stem cell transplants
  • Prevention and treatment of complications

Department of Hematology - Medical University in Poland UR

Department of Hematology - Medical University of Rzeszow Poland

The clinic has been licensed by the Ministry of Health to perform autologous and allogeneic hematopoietic cell transplants since 2022, and is accredited by the National Tissue and Cell Banking Center for the operation of the Blood Cell Bank. Hematopoietic cell transplants have been performed at the Hematology Department since 2023.

Department of Hematology - Study medicine in Poland in UR

Department of Hematology - Study medicine in Poland in University of Rzeszow

 

Modernly equipped specialized diagnostic laboratories operating within the Clinic conduct highly specialized hematological diagnostics at the highest level: Flow Cytometry Laboratory (immunophenotypic diagnosis of acute leukemia, lymphoma and plasmocytic myeloma, assessment of minimal residual disease MRD), Cytogenetics and Cytology Laboratory (classical cytogenetics and FISH) and Molecular Biology Laboratory (research by PCR and NGS methods).

The activities of the Hematology Department are supported by the Podkarpackie Association for the Development of Hematology and Bone Marrow Transplantation. The primary statutory goals of the Association are to protect and promote the health of people with blood cancers, to raise the level of treatment in the field of hematology, to secure the needs of patients requiring hemato-oncological treatment. Since 2021. The Association has the status of a Public Benefit Organization. We encourage all people of good will to give their support and donate their 1.5% tax to the Association, KRS: 0000378065.

Department of Hematology - Study medicine in Poland

Department of Hematology UR

http://stowarzyszenie-hematologia.pl/

Description of the Department's didactic activities

In the Department of Hematology, as of 2019, the didactic program in the form of exercises, seminars and lectures in hematology within the subject of internal diseases and in clinical transplantology for fifth-year students and in internal diseases for sixth-year students of the medical faculty and English Division of the College of Medical Sciences of the University of Rzeszow is implemented.

Since 2000, the Hematology Clinic has been conducting medical specializations within the framework of its accreditations in the fields of internal diseases and hematology, as well as training doctors from other centers within the framework of directed internships.

Within the framework of the Clinic, there are periodic lectures given by employees of the Clinic and invited guests, as well as doctors undergoing specialization in the field of diseases covering the subject of specialization training.

A Student Scientific Society of Hematology has been established at the Department of Hematology.
The goal of the Hematology SKN is to deepen theoretical and practical knowledge in the field of hematology, to develop the scientific activity of students, and to promote the medical faculty at the University of Rzeszow at home and abroad.

Link to SKN Hematology page: Studenckie Koło Naukowe Hematologii – Uniwersytet Rzeszowski (ur.edu.pl)