dr inż./Ph.D. Jagoda Adamczyk-Grochala
- Jednostka:
Instytut Biotechnologii/Institute of Biotechnology - Budynek: A0
- Pokój: 323
- Nr telefonu: +48178518520
- Email: [email protected]
- ORCID: 0000-0002-9535-7971
- Konsultacje dla studentów: Śr./We.14:00 p.m. pokój/room 323, A0, B2
Informacje
Disciplines
- Cell Biology
- Cancer Research
- Molecular Biology
Skills and expertise
- CRISPR-Cas Systems
- Animal Cell Culture
- Epigenetics
- Oxidative Stress
- Cell Signaling
- Techniques to Induce and Quantify Cellular Senescence
- Cytotoxicity
- DNA Damage
- Western Blot Analysis
- Immunofluorescence
- Cell Cycle Analysis
-
Immunohistochemistry
Publikacje
- [współaut.] Kaniuka O, Deręgowska A, Bandura Y [et al.] Upregulation of GRP78 is accompanied by decreased antioxidant response and mitophagy promotion in streptozotocin-induced type 1 diabetes in rats. - Biochimica et Biophysica Acta-Molecular Basis of Disease, 2025, Vol. 1871, iss.1
- [współaut.] Sendera A, Pikuła B, Cholewa M [et al.] Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro. - Toxicology in Vitro, 2024, Vol. 95
- [współaut.] Błoniarz D, Zielińska K, Lewińska A [et al.] DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis. - Apoptosis, 2023, Vol. 28, iss. 1-2, s. 166-185
- [współaut.] Lewińska A, Wnuk M TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy. - Biochimica et Biophysica Acta - Reviews on Cancer, 2023, Vol. 1878, iss. 6
- [współaut.] Ząbek T, Szmatoła T, Lewińska A [et al.] Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells. - Journal of Neuro-Oncology, 2023, Vol. 163, iss. 1, p. 61-69
- [współaut.] Betlej G, Lewińska A, Błoniarz D [et al.] Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells. - Toxicology in Vitro, 2022, Vol. 80
- [współaut.] Filip K, Lewińska A, Marino Gammazza A [et al.] 5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells. - Cells, 2022, Vol. 11, no. 7
- [współaut.] Kulpa-Greszta M, Wnuk M, Tomaszewska A [et al.] Synergic Temperature Effect of Star-like Monodisperse Iron Oxide Nanoparticles and Their Related Responses in Normal and Cancer Cells. - Journal of Physical Chemistry. B, 2022, Vol. 126, iss. 42, p. 8515-8531
- [współaut.] Lewińska A, Przybylski P, Błoniarz D [et al.] Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups. - Cancers, 2022, Vol. 14, iss. 3
- [współaut.] Lewińska A, Wróbel K, Błoniarz D [et al.] Lapatinib- and fulvestrant-PAMAM dendrimer conjugates promote apoptosis in chemotherapy-induced senescent breast cancer cells with different receptor status. - Biomaterials Advances, 2022, Vol. 140
- [współaut.] Antoniak M, Pązik R, Bazylińska U [et al.] Multimodal polymer encapsulated CdSe/Fe3O4 nanoplatform with improved biocompatibility for two-photon and temperature stimulated bioapplications. - Materials Science and Engineering C-Materials for Biological Applications, 2021, Vol. 127
- [współaut.] Błoniarz D, Lewińska A, Wnuk M The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. - Aging-US, 2021, Vol. 13, iss. 12, p. 15833-15874
- [współaut.] Potocki L, Karbarz M, Kasprzyk I [et al.] Silver birch pollen-derived microRNAs promote NF-κB-mediated inflammation in human lung cells. - Science of the Total Environment, 2021, Vol. 800
- [współaut.] Lewińska A Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells. - Cells, 2020, Vol. 9, iss. 12
- [współaut.] Lewińska A, Błoniarz D, Horeczy B [et al.] Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes in vitro. - Aging-US, 2020, Vol. 12, iss. 14, p. 13924-13938
- [współaut.] Lewińska A, Błoniarz D, Olszówka J [et al.] AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. - Redox Biology, 2020, Vol. 28, Article number 101337
- [współaut.] Pązik R, Lewińska A, Kulpa-Greszta M [et al.] Energy Conversion and Biocompatibility of Surface Functionalized Magnetite Nanoparticles with Phosphonic Moieties. - Journal of Physical Chemistry. B, 2020, Vol. 124, iss. 24, pp 4931-4948
- [współaut.] Wnuk M, Duda M, Zuczek J [et al.] Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells. - Nutrients, 2020, Vol. 12, iss. 4
- [współaut.] Lewińska A, Bocian A, Petrilla V [et al.] Snake venoms promote stress-induced senescence in human fibroblasts. - Journal of Cellular Physiology, 2019, Vol. 234, iss. 5, s. 6147-6160
- [współaut.] Lewińska A, Klukowska-Rötzler J, Deręgowska A [et al.] c-Myc activation promotes cofilin-mediated F-actin cytoskeleton remodeling and telomere homeostasis as a response to oxidant-based DNA damage in medulloblastoma cells. - Redox Biology, 2019, Vol. 24
- [współaut.] Lewińska A, Kwaśniewicz E, Deręgowska A [et al.] Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression. - Redox Biology, 2018, Vol. 14, s. 20-34
- [współaut.] Lewińska A, Bednarz D, Wnuk M Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. - Redox Biology, 2017, Vol. 12, s. 469-482
- [współaut.] Lewińska A, Deręgowska A, Wnuk M Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells. - Theranostics, 2017, Vol. 7, nr 14, pp 3461-3477
- [współaut.] Lewińska A, Kwaśniewicz E, Deręgowska A [et al.] Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. - Toxicology Letters, 2017, Vol. 265, s. 117-130
- [współaut.] Lewińska A, Kwaśniewicz E, Deręgowska A [et al.] Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. - Apoptosis, 2017, Vol. 22, iss. 6, s. 800-815
- [współaut.] Lewińska A, Kwaśniewicz E, Wnuk M Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts. - Journal of Cellular Physiology, 2017, Vol. 232, iss. 12, s. 3714-3726
- [współaut.] Deręgowska A, Panek A, Golec E [et al.] Affected chromosome homeostasis and genomic instability of clonal yeast cultures. - Current Genetics, 2016, Vol. 62, iss. 2, s. 405-418
- [współaut.] Deręgowska A, Potocki L, Kuna E [et al.] Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts. - Archives of Microbiology, 2016, Vol. 198, iss. 7, s. 715-723
- [współaut.] Deręgowska A, Skoneczny M, Skoneczna A [et al.] Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts. - Oncotarget, 2016, Vol. 7, iss. 21, s. 29958-29976
- [współaut.] Deręgowska A, Skoneczny M, Skoneczna A [et al.] Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts. - Cell Stress and Chaperones, 2016, Vol. 21, iss. 5, s. 849-864
- [współaut.] Deręgowska A, Kwiatkowska A, Gurgul A [et al.] Shifts in rDNA levels act as a genome buffer promoting chromosome homeostasis. - Cell cycle, 2015, Vol. 14, iss. 21, s. 3475-3487
- [współaut.] Deręgowska A, Skoneczny M, Kwiatkowska A [et al.] Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts. - Oncotarget, 2015, Vol. 6, nr 31, s. 30650-30663
- [współaut.] Wnuk M, Miedziak B, Kułak K [et al.] Single-cell analysis of aneuploidy events using yeast whole chromosome painting probes (WCPPs). - Journal of Microbiological Methods, 2015, Vol. 11, s. 40-49
- [współaut.] Wnuk M, Panek A, Golec E [et al.] Genetic profiling of yeast industrial strains using in situ comparative genomic hybridization (CGH). - Journal of Biotechnology, 2015, Vol. 210, s. 52-56
- [współaut.] Lewińska A, Pajak J, Stokłosa S [et al.] Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells. - Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2014, Vol. 771, s. 43-52